Lactic Acidosis - Causes

Causes

The several different causes of lactic acidosis include:

• Genetic conditions
  • Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)
  • Diabetes mellitus and deafness
  • Glucose-6-phosphatase deficiency
  • Fructose 1,6-diphosphatase deficiency
  • Pyruvate dehydrogenase deficiency
  • Pyruvate carboxylase deficiency

• Drugs
  • Phenformin
  • Metformin
  • Isoniazid toxicity
  • Nucleoside reverse transcriptase inhibitors
  • Potassium cyanide (cyanide poisoning)

• Other
  • Hypoxia and hypoperfusion
  • Hemorrhage
  • Ethanol toxicity
  • Sepsis
  • Shock
  • Hepatic disease
  • Diabetic ketoacidosis
  • Muscular exercise
  • Regional hypoperfusion (bowel ischemia, marked cellulitis...)
  • Non-Hodgkin's and Burkitt lymphomas