The Extended Series
In Dune Messiah (1969) and Children of Dune (1976), Paul and his Empire set the Imperium on a course that will ultimately last thousands of years. Much to the frustration of the Bene Gesserit, they do not control Paul or his son, Leto Atreides II, also a Kwisatz Haderach, and even their breeding program is taken from them. Jessica's infraction becomes notorious to the Sisterhood; in the coming centuries, for a Bene Gesserit to choose her love over the instructions of her order is known as "the Jessica Crime."
Leto II becomes effectively immortal by transforming into a sandworm hybrid, and oppresses humanity during his 3,500 year reign. The Bene Gesserit are subsequently terrified of accidentally producing another Kwisatz Haderach.
In Dune Messiah, the Face Dancer Scytale reveals that the Bene Tleilax "once bred a kwisatz haderach of our own." When asked how this individual was "overcome," he notes that "A creature who has spent his life creating one particular representation of his selfdom will die rather than become the antithesis of that representation." The implication is that the Tleilaxu kwisatz haderach killed himself.
Read more about this topic: Kwisatz Haderach
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