Kouilou is a department of the Republic of the Congo. Covering the country's coastline, it has an area of 13,694 square kilometres (including the commune of Pointe-Noire) and at the start of 2007 it was home to about 806,670 people (of whom 724,527 lived in Pointe-Noire). The department borders Niari Department, and internationally, Gabon and the Cabinda area of Angola. The regional capital is Pointe-Noire. Principal cities and towns include Madingo-Kayes and Mvouti.
Kouilou is also the name of a river, the Kouilou-Niari River.
Kouilou is divided into 4 districts:
- Kakamoeka District
- Madingo-Kayes District
- Mvouti District
- Pointe-Noire District
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