S
- Shanica Knowles (born 1990), actress (Beyoncé Knowles's cousin)
- Sheena Knowles, Australian children's author
- Solange Knowles (born 1986), pop/soul singer, actress, model (Beyoncé Knowles's younger sister)
- Sonny Knowles (born 1932), Irish singer
- Stanley Knowles (1908–1997), Canadian politician
- Stanley Knowles (born 1931), Australian politician
- Sydney Knowles, British frogman in World War II
- Susan Knowles (born 1951), retires Australian politician
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