Features
The features of Kallmann Syndrome (KS) and hypogonadotropic hypogonadism (HH) can be split into two different categories; "reproductive" and "non reproductive". Not all symptoms will appear in every case of KS/HH, not even amongst family members. Some of these features are linked to the gene defects known to cause KS/HH but in some cases it is still not clear why some of these features exist. It has been estimated that 60% of KS/HH cases will show a non-reproductive symptom.
It is normally difficult to distinguish a case of KS/HH from a straightforward constitutional delay of puberty. However if a boy or girl has not started puberty by either 14 (girls) or 15 (boys) and they have one of the non-reproductive features then a referral to reproductive endocrinologist might be advisable.
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