Practical Difficulties
Some fixed just intonation scales and systems, such as the diatonic scale above, produce wolf intervals. The above scale allows a minor tone to occur next to a semitone which produces the awkward ratio 32:27 for F:D, and still worse, a minor tone next to a fourth giving 40:27 for A:D. Moving D down to 10/9 alleviates these difficulties but creates new ones: G:D becomes 27:20, and B:G becomes 27:16.
You can have more frets on a guitar to handle both A's, 9/8 with respect to G and 10/9 with respect to G so that C:A can be played as 6:5 while D:A can still be played as 3:2. 9/8 and 10/9 are less than 1/53 octave apart, so mechanical and performance considerations have made this approach extremely rare. And the problem of how to tune chords such as C-E-G-A-D is left unresolved (for instance, A could be 4:3 below D (making it 9/8, if G is 1) or 4:3 above E (making it 10/9, if G is 1) but not both at the same time, so one of the fourths in the chord will have to be an out-of-tune wolf interval). However the frets may be removed entirely—this, unfortunately, makes in-tune fingering of many chords exceedingly difficult, due to the construction and mechanics of the human hand—and the tuning of most complex chords in just intonation is generally ambiguous.
Some composers deliberately use these wolf intervals and other dissonant intervals as a way to expand the tone color palette of a piece of music. For example, the extended piano pieces The Well-Tuned Piano by LaMonte Young, and The Harp Of New Albion by Terry Riley use a combination of very consonant and dissonant intervals for musical effect. In "Revelation," Michael Harrison goes even farther, and uses the tempo of beat patterns produced by some dissonant intervals as an integral part of several movements.
For many instruments tuned in just intonation, you can't change keys without retuning your instrument. For instance, if you tune a piano to just intonation intervals and a minimum of wolf intervals for the key of G, then only one other key (typically E-flat) can have the same intervals, and many of the keys have a very dissonant and unpleasant sound. This makes modulation within a piece, or playing a repertoire of pieces in different keys, impractical to impossible.
Synthesizers have proven a valuable tool for composers wanting to experiment with just intonation. Many commercial synthesizers provide the ability to use built-in just intonation scales or to program your own. Wendy Carlos used a system on her 1986 album Beauty in the Beast, where one electronic keyboard was used to play the notes, and another used to instantly set the root note to which all intervals were tuned, which allowed for modulation. On her 1987 lecture album Secrets of Synthesis there are audible examples of the difference in sound between equal temperament and just intonation.
Read more about this topic: Just Intonation
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