John Sadler may refer to:
- John Sadler (town clerk) (1615–1674), English MP and Master of Magdalene College, Cambridge
- John Sadler (1820–1910), English industrialist and public servant associated with Oldbury, West Midlands
- John Sadler (cricketer) (born 1981), English cricketer
- John Sadler (historian), British historian
- John W. Sadler (born 1956), American racehorse trainer
- John Sadler, inventor of transfer-printing
- John Sadler, instigator of the Merchant's Hope plantation
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