John Komnenos or Comnenus can refer to:
- John Komnenos (Domestic of the Schools) (fl. mid-11th century), Byzantine general, along with his wife Anna Dalassene progenitor of the Komnenian dynasty
- John II Komnenos (1087–1143), Byzantine emperor from 1118 to 1143
- John Komnenos (governor of Dyrrhachium) (fl. 1092–1106), Byzantine governor of Dyrrhachium
- John Tzelepes Komnenos, (fl. 1030–1040), Byzantine nobleman, defected to the Seljuk Turks
- John Komnenos the Fat, Byzantine nobleman, attempted a usurpation on 31 July 1200
- John Komnenos Asen (fl. 1346–1363), brother of Ivan Alexander of Bulgaria, Serbian despot of Aulon and Venetian subject
- John Komnenos Vatatzes (fl. 1132-1182), Byzantine general, grandson of John II Komnenos.
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