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- John Griffin (Allegany County, New York) (c. 1771–1846), New York politician
- John Griffin (judge) (1774/1779 – after 1823), American jurist and member of the Michigan Territorial Supreme Court, 1806–1823
- John Griffin, 4th Baron Howard de Walden (1719–1797), English nobleman and army officer
- John Howard Griffin (1920–1980), American journalist and novelist
- John Joseph Griffin (1802–1877), English chemist and publisher
- John K. Griffin (1789–1841), U.S. Congressman from South Carolina, 1831–1841
- John Smith Griffin (1807–1899), American missionary in Oregon Country
- John Strother Griffin (1816–1898), American surgeon and politician in Los Angeles
- John W. Griffin (archaeologist) (1919–1993), American historian in Florida
- John W. Griffin (politician) (1927–2006), American local political figure in Ohio
- Johnny Griffin (1928–2008), American bop and hard bop tenor saxophonist
- John Griffin, founder of the UK's largest minicab business, Addison Lee
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