John Eccles may refer to:
- John Eccles (neurophysiologist) (1903–1997), Australian neurophysiologist
- John Eccles (composer) (1668–1735), English composer
- John Eccles, 2nd Viscount Eccles (born 1931), British businessman
- John Eccles (Royal Navy officer) (1898–1966)
- John Scott Eccles, a fictional character and the client of Sherlock Holmes in "The Adventure of Wisteria Lodge"
- Jack Eccles (1869–1932), English footballer with Stoke