Professional Record
| 66 Wins (52 knockouts, 13 decisions, 1 disqualification), 3 Losses (2 knockouts, 1 decision), 1 No Contest | |||||||
| Res. | Record | Opponent | Type | Round | Date | Location | Notes |
| Loss | 66–3-(1) | Rocky Marciano | TKO | 8 (10) | 26/10/1951 | Madison Square Garden, New York, New York, United States | |
| Win | 66–2-(1) | Jimmy Bivins | UD | 10 | 15/08/1951 | Memorial Stadium, Baltimore, Maryland, United States | |
| Win | 65–2-(1) | Cesar Brion | UD | 10 | 01/08/1951 | Cow Palace, San Francisco, California, United States | |
| Win | 64–2-(1) | Lee Savold | KO | 6 (15) | 15/06/1951 | Madison Square Garden, New York, New York, United States | |
| Win | 63–2-(1) | Omelio Agramonte | UD | 10 | 02/05/1951 | Olympia Stadium, Detroit, Michigan, United States | |
| Win | 62–2-(1) | Andy Walker | TKO | 10 (10) | 23/02/1951 | Cow Palace, San Francisco, California, United States | |
| Win | 61–2-(1) | Omelio Agramonte | UD | 10 | 07/02/1951 | Miami Stadium, Miami, Florida, United States | |
| Win | 60–2-(1) | Freddie Beshore | TKO | 4 (10) | 03/01/1951 | Olympia Stadium, Detroit, Michigan, United States | |
| Win | 59–2-(1) | Cesar Brion | UD | 10 | 29/11/1950 | Chicago Stadium, Chicago, Illinois, United States | |
| Loss | 58–2-(1) | Ezzard Charles | UD | 15 | 27/09/1950 | Yankee Stadium, Bronx, New York, United States | For World Heavyweight title. |
| NC | 58–1-(1) | Johnny Shkor | ND | 10 | 14/11/1949 | Boston Garden, Boston, Massachusetts, United States | |
| Win | 58–1 | Jersey Joe Walcott | KO | 11 (15) | 25/06/1948 | Yankee Stadium, Bronx, New York, United States | Retained World Heavyweight title. Louis announced his retirement on March 1, 1949. |
| Win | 57–1 | Jersey Joe Walcott | SD | 15 | 05/12/1947 | Madison Square Garden, New York, New York, United States | Retained World Heavyweight title. |
| Win | 56–1 | Tami Mauriello | KO | 1 (15) | 18/09/1946 | Yankee Stadium, Bronx, New York, United States | Retained World Heavyweight title. |
| Win | 55–1 | Billy Conn | KO | 8 (15) | 19/06/1946 | Yankee Stadium, Bronx, New York, United States | Retained World Heavyweight title. |
| Win | 54–1 | Johnny Davis | TKO | 1 (4) | 14/11/1944 | Memorial Auditorium, Buffalo, New York, United States | Heavyweight title at stake per NYSAC ruling. |
| Win | 53–1 | Abe Simon | TKO | 6 (15) | 27/03/1942 | Madison Square Garden, New York, New York, United States | Retained World Heavyweight title. |
| Win | 52–1 | Buddy Baer | KO | 1 (15) | 09/01/1942 | Madison Square Garden, New York, New York, United States | Retained World Heavyweight title. |
| Win | 51–1 | Lou Nova | TKO | 6 (15) | 29/09/1941 | Polo Grounds, New York, New York, United States | Retained World Heavyweight title. |
| Win | 50–1 | Billy Conn | KO | 13 (15) | 18/06/1941 | Polo Grounds, New York, New York, United States | Retained World Heavyweight title. 1941 Fight of the Year by The Ring Magazine. |
| Win | 49–1 | Buddy Baer | DQ | 7 (15) | 23/05/1941 | Griffith Stadium, District of Columbia, United States | Retained World Heavyweight title. |
| Win | 48–1 | Tony Musto | TKO | 9 (15) | 08/04/1941 | Arena, St. Louis, Missouri, United States | Retained World Heavyweight title. |
| Win | 47–1 | Abe Simon | TKO | 13 (20) | 21/03/1941 | Olympia Stadium, Detroit, Michigan, United States | Retained World Heavyweight title. |
| Win | 46–1 | Gus Dorazio | KO | 2 (15) | 17/02/1941 | Convention Hall, Philadelphia, Pennsylvania, United States | Retained World Heavyweight title. |
| Win | 45–1 | Red Burman | KO | 5 (15) | 31/01/1941 | Madison Square Garden, New York, New York, United States | Retained World Heavyweight title. |
| Win | 44–1 | Al McCoy | TKO | 6 (15) | 16/12/1940 | Boston Garden, Boston, Massachusetts, United States | Retained World Heavyweight title. |
| Win | 43–1 | Arturo Godoy | TKO | 8 (15) | 20/06/1940 | Yankee Stadium, Bronx, New York, United States | Retained World Heavyweight title. |
| Win | 42–1 | Johnny Paychek | TKO | 2 (15) | 29/03/1940 | Madison Square Garden, New York, New York, United States | Retained World Heavyweight title. |
| Win | 41–1 | Arturo Godoy | SD | 15 | 09/02/1940 | Madison Square Garden, New York, New York, United States | Retained World Heavyweight title. |
| Win | 40–1 | Bob Pastor | KO | 11 (20) | 20/09/1939 | Briggs Stadium, Detroit, Michigan, United States | Retained World Heavyweight title. 1939 Fight of the Year by The Ring Magazine. |
| Win | 39–1 | Tony Galento | TKO | 4 (15) | 28/06/1939 | Yankee Stadium, Bronx, New York, United States | Retained World Heavyweight title. |
| Win | 38–1 | Jack Roper | KO | 1 (10) | 17/04/1939 | Wrigley Field, Los Angeles, California, United States | Retained World Heavyweight title. |
| Win | 37–1 | John Henry Lewis | KO | 1 (15) | 25/01/1939 | Madison Square Garden, New York, New York, United States | Retained World Heavyweight title. |
| Win | 36–1 | Max Schmeling | KO | 1 (15) | 22/06/1938 | Yankee Stadium, Bronx, New York, United States | Retained World Heavyweight title. Proclaimed the "Fight of the Decade" by The Ring Magazine. |
| Win | 35–1 | Harry Thomas | KO | 5 (15) | 01/04/1938 | Chicago Stadium, Chicago, Illinois, United States | Retained World Heavyweight title. |
| Win | 34–1 | Nathan Mann | KO | 3 (15) | 23/02/1938 | Madison Square Garden, New York, New York, United States | Retained World Heavyweight title. |
| Win | 33–1 | Tommy Farr | UD | 15 | 30/08/1937 | Yankee Stadium, Bronx, New York, United States | Retained World Heavyweight title. 1937 Fight of the Year by The Ring Magazine. |
| Win | 32–1 | James Braddock | KO | 8 (15) | 22/06/1937 | Comiskey Park, Chicago, Illinois, United States | Won World Heavyweight title. |
| Win | 31–1 | Natie Brown | KO | 4 (10) | 17/02/1937 | Municipal Auditorium, Kansas City, Missouri, United States | |
| Win | 30–1 | Bob Pastor | UD | 10 | 29/01/1937 | Madison Square Garden, New York, New York, United States | |
| Win | 29–1 | Steve Ketchel | KO | 2 (4) | 11/01/1937 | Broadway Auditorium, Buffalo, New York, United States | |
| Win | 28–1 | Eddie Simms | TKO | 1 (10) | 14/12/1936 | Public Hall, Cleveland, Ohio, United States | |
| Win | 27–1 | Jorge Brescia | KO | 3 (10) | 09/10/1936 | Hippodrome, New York, New York, United States | |
| Win | 26–1 | Al Ettore | KO | 5 (15) | 22/09/1936 | Municipal Stadium, Philadelphia, Pennsylvania, United States | |
| Win | 25–1 | Jack Sharkey | KO | 3 (10) | 18/08/1936 | Yankee Stadium, Bronx, New York, United States | |
| Loss | 24–1 | Max Schmeling | KO | 12 (15) | 19/06/1936 | Yankee Stadium, Bronx, New York, United States | 1936 Fight of the Year by The Ring Magazine. |
| Win | 24–0 | Charley Retzlaff | KO | 1 (15) | 17/01/1936 | Chicago Stadium, Chicago, Illinois, United States | |
| Win | 23–0 | Paulino Uzcudun | TKO | 4 (15) | 13/12/1935 | Madison Square Garden, New York, New York, United States | |
| Win | 22–0 | Max Baer | KO | 4 (15) | 24/09/1935 | Yankee Stadium, Bronx, New York, United States | 1935 Fight of the Year by The Ring Magazine. |
| Win | 21–0 | King Levinsky | TKO | 1 (10) | 07/08/1935 | Comiskey Park, Chicago, Illinois, United States | |
| Win | 20–0 | Primo Carnera | TKO | 6 (15) | 25/06/1935 | Yankee Stadium, Bronx, New York, United States | |
| Win | 19–0 | Biff Bennett | KO | 1 (6) | 22/04/1935 | Memorial Hall, Dayton, Ohio, United States | |
| Win | 18–0 | Roy Lazer | KO | 3 (10) | 12/04/1935 | Chicago Stadium, Chicago, Illinois, United States | |
| Win | 17–0 | Natie Brown | UD | 10 | 29/03/1935 | Olympia Stadium, Detroit, Michigan, United States | |
| Win | 16–0 | Don "Red" Barry | TKO | 3 (10) | 08/03/1935 | Dreamland Auditorium, San Francisco, California, United States | |
| Win | 15–0 | Lee Ramage | TKO | 2 (10) | 21/02/1935 | Wrigley Field, Los Angeles, California, United States | |
| Win | 14–0 | Hans Birkie | TKO | 10 (10) | 11/01/1935 | Duquesne Gardens, Pittsburgh, Pennsylvania, United States | |
| Win | 13–0 | Patsy Perroni | PTS | 10 | 04/01/1935 | Olympia Stadium, Detroit, Michigan, United States | |
| Win | 12–0 | Lee Ramage | TKO | 8 (10) | 14/12/1934 | Chicago Stadium, Chicago, Illinois, United States | |
| Win | 11–0 | Charley Massera | KO | 3 (10) | 30/11/1934 | Coliseum, Chicago, Illinois, United States | |
| Win | 10–0 | Stanley Poreda | KO | 1 (10) | 14/11/1934 | Arcadia Gardens, Chicago, Illinois, United States | |
| Win | 9–0 | Jack O'Dowd | KO | 2 (10) | 31/10/1934 | Arcadia Gardens, Chicago, Illinois, United States | |
| Win | 8–0 | Art Sykes | KO | 8 (10) | 24/10/1934 | Arcadia Gardens, Chicago, Illinois, United States | |
| Win | 7–0 | Adolph Wiater | PTS | 10 | 26/09/1934 | Arcadia Gardens, Chicago, Illinois, United States | |
| Win | 6–0 | Al Delaney | TKO | 4 (10) | 11/09/1934 | Naval Armory, Detroit, Michigan, United States | |
| Win | 5–0 | Buck Everett | KO | 2 (8) | 27/08/1934 | Marigold Gardens Outdoor Arena, Chicago, Illinois, United States | |
| Win | 4–0 | Jack Kranz | UD | 8 | 13/08/1934 | Marigold Gardens Outdoor Arena, Chicago, Illinois, United States | |
| Win | 3–0 | Larry Udell | TKO | 2 (8) | 30/07/1934 | Marigold Gardens Outdoor Arena, Chicago, Illinois, United States | |
| Win | 2–0 | Willie Davies | ТKO | 3 (6) | 12/07/1934 | Bacon's Arena, Chicago, Illinois, United States | |
| Win | 1–0 | Jack Kracken | KO | 1 (6) | 04/07/1934 | Bacon's Arena, Chicago, Illinois, United States | |
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