| Year | Filmography | Roles | Notes |
|---|---|---|---|
| 1964 | Lilith | Laura | |
| 1966 | Grand Prix | Pat Stoddard | Golden Globe Award for Most Promising Newcomer - Female |
| 1966 | The Group | Libby | |
| 1968 | Bye Bye Braverman | Inez Braverman | |
| 1969 | Number One | Julie Catlan | |
| 1971 | Play Misty For Me | Evelyn Draper | Nominated — Golden Globe Award for Best Actress – Motion Picture Drama |
| 1974 | Columbo: Mind Over Mayhem | Dr. Margaret Nicholson | |
| 1974–1975 | Amy Prentiss | Amy Prentiss | TV series Emmy Award for Outstanding Lead Actress – Miniseries or a Movie |
| 1977 | "The New Adventures of Wonder Woman (TV Series)" | Gloria | |
| 1978 | Dr. Strange | Morgan le Fay | (TV) |
| 1979 | Goldengirl | ||
| 1979 | Vampire | Nicole DeCamp | (TV film) |
| 1981 | Going Ape! | Fiona | |
| 1982 | Spring Fever | Celia Berryman | |
| 1984 | Terror in the Aisles | Evelyn Draper | Archival - segment Play Misty for Me |
| 1984 | The Flamingo Kid | Phyllis Brody | |
| 1984 | Secret Places | Girl #1 in art room | |
| 1986 | Novel Connection & Magnum on Ice | Joan Forrester | Crossover episode of Magnum PI and Murder She Wrote |
| 1988 | Tapeheads | Kay Mart | |
| 1991–1995 | Dinosaurs | Fran Sinclair (voice) | |
| 1993 | Ghost in the Machine | Elaine | aka Deadly Terror |
| 1994 | PCU | President Garcia-Thompson | |
| 1994 | Babylon 5 | Senator Elise Voudreau | (1 episode, A Spider in the Web) |
| 1995 | Temptress | Dr. Phyllis Evergreen | |
| 1998 | Slums of Beverly Hills | Doris Zimmerman | |
| 2001 | My Best Friend's Wife | Mrs. Epstein | |
| 2003 | Dummy | Fern Schoichet | |
| 2003–2006, 2013 | Arrested Development | Lucille Bluth | (53 episodes) Satellite Award for Best Supporting Actress – Series, Miniseries or Television Film (2003) TV Land Award for Future Classic (2004) Nominated — Emmy Award for Outstanding Supporting Actress – Comedy Series (2005) Nominated — Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Comedy Series (2005, 2006) |
| 2006 | Unaccompanied Minors | Cindi | |
| 2007-2010 | Saving Grace | Betty Hanadarko | (5 episodes) |
| 2007 | Rules of Engagement | Constance | (1 episode, Kids) |
| 2008 | Law & Order: Criminal Intent | Eleanor Reynolds | (1 episode) |
| 2008–2009 | 90210 | Tabitha Wilson | series regular (13 episodes) |
| 2009 | Make It Or Break It | Grandma Tanner | (1 episode, Battle of the Flexes) |
| 2009 | Law & Order: SVU | Attorney Petra Gilmartin | |
| 2009–present | Archer | Malory Archer | series regular |
| 2011–present | Retired at 35 | Elaine Robbins | series regular |
| 2011 | The Big Bang Theory | Mrs. Latham | (1 episode, The Benefactor Factor) |
| 2012 | Bending the Rules | Lena Gold | |
| 2013 | Arrested Development | Lucille Bluth | (filming) |
Read more about this topic: Jessica Walter