The Janus Kinase Family
The four JAK family members are:
- Janus kinase 1 (JAK1)
- Janus kinase 2 (JAK2)
- Janus kinase 3 (JAK3)
- Tyrosine kinase 2 (TYK2)
Transgenic mice that do not express JAK1 have defective responses to some cytokines, such as interferon-gamma. JAK1 and JAK2 are involved in type II interferon (interferon-gamma) signalling, whereas JAK1 and TYK2 are involved in type I interferon signalling. Mice that do not express TYK2 have defective natural killer cell function.
Read more about this topic: Janus Kinase
Famous quotes containing the word family:
“My ambition for station was always easily controlled. If the place came to me it was welcome. But it never seemed to me worth seeking at the cost of self-respect, or independence. My family were not historic; they were well-to-do, did not hold or seek office. It was easy for me to be contented in private life. An honor was no honor to me, if obtained by my own seeking.”
—Rutherford Birchard Hayes (1822–1893)