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- James Douglas (physician) (1675–1742), Scottish anatomist and physician
- James Douglas (businessman) (1837–1918), Canadian-born U.S. mining engineer, industrialist, and philanthropist
- James Douglas, Jr. (1868–1949), Canadian-American businessman and mining executive
- James Douglas (composer) (born 1932), Scottish composer
- James Douglas (journalist) (1867–1940), British newspaper editor, author and critic
- James Douglas (actor) (born 1933), American soap opera actor
- James Douglas (voice actor)
- James W. B. Douglas, social researcher
- James Douglas (architect), American architect in Wisconsin
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