People
- Isaac Smith (Royal Navy officer) (1752–1831), Royal Navy officer and the first European to set foot in eastern Australia
- Isaac Smith (New Jersey) (1740–1807), United States Representative from New Jersey
- Isaac Smith (Pennsylvania) (1761–1834), United States Representative from Pennsylvania
- Isaac E. Smith (1858–1940), boat builder who built the first Star Class sailboats
- Isaac W. Smith (California politician)
- Isaac W. Smith (New Hampshire politician)
- Isaac W. Smith (surveyor) (1826–1897), American soldier and surveyor
- Isaac Smith (footballer) (born 1988), Australian rules footballer
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