Isaac Komnenos or Isaac Comnenus may refer to:
- Isaac I Komnenos (c. 1007 – 1061), emperor
- Isaac Komnenos (brother of Alexios I) (c. 1050 – 1102/1104), nephew of Isaac I Komnenos and elder brother of Alexios I
- Isaac Komnenos (son of Alexios I) (16 January 1093 – after 1152), son of Byzantine Emperor Alexios I Komnenos and Empress Irene Doukaina
- Isaac Komnenos (son of John II) (c. 1113 – after 1154), son of Byzantine Emperor John II Komnenos and Piroska of Hungary
- Isaac Komnenos of Cyprus (c. 1155 – 1195/1196)
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