Pathology
The IPE is affected by glaucoma, diabetes, and iris inflammations and atrophies of various kinds, generally responding by showing patchy thinning and depigmentation. In albinism, it is fully or partially nonpigmented and translucent, which contributes to the photophobia of that condition. However, diseases specific to the IPE itself are almost non-existent, and it seems to be a highly differentiated, stable cell type that almost never gives rise to malignancies, unlike the melanocytes of the iris stroma. Reports of adenomas and adenocarcinomas of the IPE exist, but some of these are debatable.
Read more about this topic: Iris Pigment Epithelium
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—Bronislaw Geremek (b. 1932)