Disease Relevance
In cardiomyopathy the heart reverts to a fetal gene programming due to the overload of the heart. Like during fetal development, thyroid hormone levels are low in the overloaded heart tissue in a local hypothyroid state, with low levels of Deiodinase 1 and Deiodinase 2. Although Deiodinase 3 levels in a normal heart are generally low, in cardiomyopathy Deiodinase 3 activity is increased to decrease energy turnover and oxygen consumption.
Read more about this topic: Iodothyronine Deiodinase
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