Formation of Bone Spicules
Embryologic mesenchymal cells (MSC) condense into layers of vascularized primitive connective tissue. Certain mesenchymal cells group together, usually near or around blood vessels, and differentiate into osteogenic cells which deposit bone matrix constitutively. These aggregates of bony matrix are called bone spicules. Separate mesenchymal cells differentiate into osteoblasts, which line up along the surface of the spicule and secrete more osteoid, which increases the size of the spicule.
Read more about this topic: Intramembranous Ossification
Famous quotes containing the words formation of, formation and/or bone:
“Out of my discomforts, which were small enough, grew one thing for which I have all my life been grateful—the formation of fixed habits of work.”
—Elizabeth Stuart Phelps (1844–1911)
“The moral virtues, then, are produced in us neither by nature nor against nature. Nature, indeed, prepares in us the ground for their reception, but their complete formation is the product of habit.”
—Aristotle (384–322 B.C.)
“The wealth and prosperity of the country are only the comeliness of the body, the fullness of the flesh and fat; but the spirit is independent of them; it requires only muscle, bone and nerve for the true exercise of its functions. We cannot lose our liberty, because we cannot cease to think.”
—Humphry, Sir Davy (1778–1829)