Formation of Bone Spicules
Embryologic mesenchymal cells (MSC) condense into layers of vascularized primitive connective tissue. Certain mesenchymal cells group together, usually near or around blood vessels, and differentiate into osteogenic cells which deposit bone matrix constitutively. These aggregates of bony matrix are called bone spicules. Separate mesenchymal cells differentiate into osteoblasts, which line up along the surface of the spicule and secrete more osteoid, which increases the size of the spicule.
Read more about this topic: Intramembranous Ossification
Famous quotes containing the words formation of, formation and/or bone:
“I want you to consider this distinction as you go forward in life. Being male is not enough; being a man is a right to be earned and an honor to be cherished. I cannot tell you how to earn that right or deserve that honor. . . but I can tell you that the formation of your manhood must be a conscious act governed by the highest vision of the man you want to be.”
—Kent Nerburn (20th century)
“The moral virtues, then, are produced in us neither by nature nor against nature. Nature, indeed, prepares in us the ground for their reception, but their complete formation is the product of habit.”
—Aristotle (384–322 B.C.)
“Here lies the body of William Jones
Who all his life collected bones,
Till Death, that grim and boney spectre,
That universal bone collector,
Boned old Jones, so neat and tidy,
And here he lies, all bona fide.”
—Anonymous. “Epitaph on William Jones,” from Eleanor Broughton’s Varia (1925)