Interstate 376

Interstate 376 (I-376) is a major auxiliary route of the Interstate Highway System in the U.S. state of Pennsylvania, located entirely within the Allegheny Plateau. It runs from I-80 near Sharon south and east to a junction with the Pennsylvania Turnpike (I-76, its parent) in Monroeville, after having crossed the Turnpike at an interchange earlier in its route. The route serves Pittsburgh, Pennsylvania and its surrounding areas, and is the main access road to Pittsburgh International Airport (PIT). Within Allegheny County, the route runs along the majority of the Penn-Lincoln Parkway, known locally as the Parkway West and the Parkway East. The route is also known by several other names in various jurisdictions. It is currently the fifth-longest auxiliary Interstate route in the system, and second only to I-476 within the Commonwealth of Pennsylvania.

I-376 is signed east–west despite running north–south for nearly three-quarters of its length; however, it does run east–west through the majority of Allegheny County. This is due to the fact that when the route was first conceived, it was an east–west highway that only connected I-279 in Downtown Pittsburgh to the Turnpike in Monroeville. Despite the route's direction, it serves as a major artery through Pittsburgh's West End, with I-79 being the primary route through Pittsburgh's North Hills. Since its 2009 extension, the route has also served as access to Youngstown, Ohio (through both I-76 & I-80) and, ultimately, Akron, Ohio via I-76, Columbus, Ohio via I-76 & I-71, and Cleveland via I-80.

A 16-mile (26 km) stretch, from exit 15 where I-376 ends its brief concurrency with U.S. Route 422 (US 422) to exit 31 where I-376 has its first intersection with Pennsylvania Route 51 (PA 51), is tolled and is maintained by the Pennsylvania Turnpike Commission, while the remainder of the highway is maintained by PennDOT. Near the airport, I-376 also has a business loop route (BL-376).