Related Growth Factors
IGF-1 is closely related to a second protein called "IGF-2". IGF-2 also binds the IGF-1 receptor. However, IGF-2 alone binds a receptor called the "IGF-2 receptor" (also called the mannose-6 phosphate receptor). The insulin growth factor-II receptor (IGF2R) lacks signal transduction capacity, and its main role is to act as a sink for IGF-2 and make less IGF-2 available for binding with IGF-1R. As the name "insulin-like growth factor 1" implies, IGF-1 is structurally related to insulin, and is even capable of binding the insulin receptor, albeit at lower affinity than insulin.
A splice variant of IGF-1 sharing an identical mature region, but with a different E domain is known as mechano growth factor (MGF).
Read more about this topic: Insulin-like Growth Factor 1
Famous quotes containing the words related, growth and/or factors:
“One does not realize the historical sensation as a re-experiencing, but as an understanding that is closely related to the understanding of music, or rather of the world by means of music.”
—Johan Huizinga (1872–1945)
“A person of mature years and ripe development, who is expecting nothing from literature but the corroboration and renewal of past ideas, may find satisfaction in a lucidity so complete as to occasion no imaginative excitement, but young and ambitious students are not content with it. They seek the excitement because they are capable of the growth that it accompanies.”
—Charles Horton Cooley (1864–1929)
“The goal of every culture is to decay through over-civilization; the factors of decadence,—luxury, scepticism, weariness and superstition,—are constant. The civilization of one epoch becomes the manure of the next.”
—Cyril Connolly (1903–1974)