Role of Hormones
Age distribution and relation to breastfeeding duration is suggestive of some sort of involvement of hormones in the aetiology, however significant differences exist compared to normal breast cancer.
Typically IBC shows low levels of estrogen and progesterone receptor sensitivity corresponding with poor outcome. In cases with positive estrogen receptor status antihormonal treatment is believed to improve outcome.
Paradoxically some findings suggest that especially aggressive phenotypes of IBC are characterised by high level of NF kappaB target gene expression which can be - under laboratory conditions successfully modulated by estrogen but not tamoxifen.
Read more about this topic: Inflammatory Breast Cancer
Famous quotes containing the words role of, role and/or hormones:
“The traditional American husband and father had the responsibilities—and the privileges—of playing the role of primary provider. Sharing that role is not easy. To yield exclusive access to the role is to surrender some of the potential for fulfilling the hero fantasy—a fantasy that appeals to us all. The loss is far from trivial.”
—Faye J. Crosby (20th century)
“A famous theatrical actress
Played best in the role of malefactress.
Yet her home-life was pure
Except, to be sure,
A scandal or two just for practice.”
—Anonymous.
“Teenage boys, goaded by their surging hormones ... run in packs like the primal horde. They have only a brief season of exhilarating liberty between control by their mothers and control by their wives.”
—Camille Paglia (b. 1947)