In Vivo - Methods of Use

Methods of Use

According to Christopher Lipinski and Andrew Hopkins, "Whether the aim is to discover drugs or to gain knowledge of biological systems, the nature and properties of a chemical tool cannot be considered independently of the system it is to be tested in. Compounds that bind to isolated recombinant proteins are one thing; chemical tools that can perturb cell function another; and pharmacological agents that can be tolerated by a live organism and perturb its systems are yet another. If it were simple to ascertain the properties required to develop a lead discovered in vitro to one that is active in vivo, drug discovery would be as reliable as drug manufacturing."

Read more about this topic:  In Vivo

Famous quotes containing the words methods of and/or methods:

    All men are equally proud. The only difference is that not all take the same methods of showing it.
    François, Duc De La Rochefoucauld (1613–1680)

    The reading public is intellectually adolescent at best, and it is obvious that what is called “significant literature” will only be sold to this public by exactly the same methods as are used to sell it toothpaste, cathartics and automobiles.
    Raymond Chandler (1888–1959)