Disadvantages of in Vitro Studies
The primary disadvantage of in vitro experimental studies is that it can sometimes be very challenging to extrapolate from the results of in vitro work back to the biology of the intact organism. Investigators doing in vitro work must be careful to avoid over-interpretation of their results, which can sometimes lead to erroneous conclusions about organismal and systems biology.
For example, scientists developing a new viral drug to treat an infection with a pathogenic virus (e.g. HIV-1) may find that a candidate drug functions to prevent viral replication in an in vitro setting (typically cell culture). However, before this drug is used in the clinic, it must progress through a series of in vivo trials to determine if it is safe and effective in intact organisms (typically small animals, primates and humans in succession). Typically, many candidate drugs that are effective in vitro prove to be ineffective in vivo because of issues associated with delivery of the drug to the affected tissues, or toxicity towards essential parts of the organism that were not represented in the initial in vitro studies.
Read more about this topic: In Vitro
Famous quotes containing the words disadvantages of and/or studies:
“Wine makes a man better pleased with himself. I do not say that it makes him more pleasing to others.... This is one of the disadvantages of wine, it makes a man mistake words for thoughts.”
—Samuel Johnson (1709–1784)
“The conduct of a man, who studies philosophy in this careless manner, is more truly sceptical than that of any one, who feeling in himself an inclination to it, is yet so over-whelm’d with doubts and scruples, as totally to reject it. A true sceptic will be diffident of his philosophical doubts, as well as of his philosophical conviction; and will never refuse any innocent satisfaction, which offers itself, upon account of either of them.”
—David Hume (1711–1776)