Disadvantages of in Vitro Studies
The primary disadvantage of in vitro experimental studies is that it can sometimes be very challenging to extrapolate from the results of in vitro work back to the biology of the intact organism. Investigators doing in vitro work must be careful to avoid over-interpretation of their results, which can sometimes lead to erroneous conclusions about organismal and systems biology.
For example, scientists developing a new viral drug to treat an infection with a pathogenic virus (e.g. HIV-1) may find that a candidate drug functions to prevent viral replication in an in vitro setting (typically cell culture). However, before this drug is used in the clinic, it must progress through a series of in vivo trials to determine if it is safe and effective in intact organisms (typically small animals, primates and humans in succession). Typically, many candidate drugs that are effective in vitro prove to be ineffective in vivo because of issues associated with delivery of the drug to the affected tissues, or toxicity towards essential parts of the organism that were not represented in the initial in vitro studies.
Read more about this topic: In Vitro
Famous quotes containing the words disadvantages of and/or studies:
“One of the disadvantages of being a patrician is that occasionally you’re obliged to act like one.”
—Dalton Trumbo (1905–1976)
“His life itself passes deeper in nature than the studies of the naturalist penetrate; himself a subject for the naturalist. The latter raises the moss and bark gently with his knife in search of insects; the former lays open logs to their core with his axe, and moss and bark fly far and wide. He gets his living by barking trees. Such a man has some right to fish, and I love to see nature carried out in him.”
—Henry David Thoreau (1817–1862)