Peripheral Tolerance
Peripheral tolerance is immunological tolerance developed after T and B cells mature and enter the periphery. The T cells that leave the thymus are relatively but not completely safe.Some will have receptors(TCRs) that can respond to self antigens that:
- are present in such high concentration that they can bind to "weak" receptors
- the T cell did not encounter in the thymus (such as, tissue-specific molecules like those in the islets of Langerhans, brain or spinal cord)
Those self reactive T cells that escape intrathymic negative selection in the thymus can inflict cell injury unless they are deleted or effectively muzzled in the peripheral tissue.several back michanism silence such potentially auto reactive T cells are known to exist. they include following:
♥Anergy ♠activation-induced cell death ♣Peripheral supression cell deathRead more about this topic: Immune Tolerance
Famous quotes containing the words peripheral and/or tolerance:
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—David Hockney (b. 1937)
“The tradition I cherish is the ideal this country was built upon, the concept of religious pluralism, of a plethora of opinions, of tolerance and not the jihad. Religious war, pooh. The war is between those who trust us to think and those who believe we must merely be led.”
—Anna Quindlen (b. 1952)