Peripheral Tolerance
Peripheral tolerance is immunological tolerance developed after T and B cells mature and enter the periphery. The T cells that leave the thymus are relatively but not completely safe.Some will have receptors(TCRs) that can respond to self antigens that:
- are present in such high concentration that they can bind to "weak" receptors
- the T cell did not encounter in the thymus (such as, tissue-specific molecules like those in the islets of Langerhans, brain or spinal cord)
Those self reactive T cells that escape intrathymic negative selection in the thymus can inflict cell injury unless they are deleted or effectively muzzled in the peripheral tissue.several back michanism silence such potentially auto reactive T cells are known to exist. they include following:
♥Anergy ♠activation-induced cell death ♣Peripheral supression cell deathRead more about this topic: Immune Tolerance
Famous quotes containing the words peripheral and/or tolerance:
“If we are to change our world view, images have to change. The artist now has a very important job to do. He’s not a little peripheral figure entertaining rich people, he’s really needed.”
—David Hockney (b. 1937)
“Advocating the mere tolerance of difference between women is the grossest reformism. It is a total denial of the creative function of difference in our lives. Difference must be not merely tolerated, but seen as a fund of necessary polarities between which our creativity can spark like a dialectic.”
—Audre Lorde (1934–1992)