Breadth of The Hypothesis
The hygiene hypothesis has expanded from eczema and hay fever to include exposure to several varieties of microorganisms and parasites, with which humans coexisted throughout much of our evolutionary history, as necessary for balanced and regulated immune system development. In recent times, the development of hygienic practices, elimination of childhood diseases, widespread use of antibiotics, and relative availability of effective medical care have diminished or eliminated exposure to these microorganisms and parasites during development. Examples of organisms that may be important for proper development of T regulatory cells include lactobacilli, various mycobacteria, and certain helminths.
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“Fogs and clouds which conceal the overshadowing mountains lend the breadth of the plains to mountain vales. Even the small-featured country acquires some grandeur in stormy weather when clouds are seen drifting between the beholder and the neighboring hills.”
—Henry David Thoreau (1817–1862)
“Fogs and clouds which conceal the overshadowing mountains lend the breadth of the plains to mountain vales. Even the small-featured country acquires some grandeur in stormy weather when clouds are seen drifting between the beholder and the neighboring hills.”
—Henry David Thoreau (1817–1862)
“And my spirit is grown to a lordly great compass within,
That the length and the breadth and the sweep of the marshes of
Glynn
Will work me no fear like the fear they have wrought me of yore
When length was failure, and when breadth was but bitterness sore,
And when terror and shrinking and dreary unnamable pain
Drew over me out of the merciless miles of the plain,—
Oh, now, unafraid, I am fain to face
The vast sweet visage of space.”
—Sidney Lanier (1842–1881)
“The wheels and springs of man are all set to the hypothesis of the permanence of nature. We are not built like a ship to be tossed, but like a house to stand.”
—Ralph Waldo Emerson (1803–1882)