Hugh le Despenser may refer to:
- Hugh le Despenser I (died 1238)
- Hugh le Despencer, 1st Baron le Despencer (1223–1265)
- Hugh le Despencer, 2nd Baron le Despencer (1308–1349)
- Hugh le Despenser, 1st Earl of Winchester (1262–1326), a.k.a. Hugh the elder Despenser
- Hugh Despenser the Younger (1286–1326)
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