2010s
Helena showed up in Port Charles again on February 10, following her learning of Nikolas' affair with Elizabeth Webber. The following day, Elizabeth finds out she is pregnant. Believing the baby is Nikolas's, Helena made immediate threats to Elizabeth about the welfare of the child. Believing she is unstable, Nikolas and Lucky pressure her into committing herself into Shadybrook Sanitarium. In an attempt to keep tabs on Elizabeth, Helena makes a large donation to the institution, getting an upperhand with the staff. While reminiscing with Luke, she reveals the immediate threat from Valentin has passed. Later, when Elizabeth has a paternity test done, Helena pays the lab tech to let her see the results first. She finds out Lucky is the biological father, but has the results switched to make it look like Nikolas is the father. Helena has her Man kidnap Tracy who she thought knew Liz's baby was a Spencer. Luke tries to find Tracy but ends up kidnapped, too. While they are being held hostage, Tracy becomes sick and Luke takes care of her. Later Nikolas and Lucky find Tracy and Luke. Upon returning to Port Charles, Nikolas banishes Helena from Wyndemere for her actions and warns her to stay away from Elizabeth and their son. When the newborn Aiden is later kidnapped, Helena instantly becomes a suspect, and Nik openly threatens to kill her if she is the one who did so. Eventually, Aiden is found unharmed.
Over time, Elizabeth suspects that Aiden is Lucky's son, not Nikolas', and confirms this with a third DNA test. After delaying this revelation when Elizabeth's middle child Jake is killed in a hit-and run accident, she finally reveals the truth to Lucky and Nikolas. Nikolas does not take the news well, and decides to leave Aiden with Elizabeth and Lucky, then prepares to leave town. Helena is seen in Port Charles secretly watching Nikolas as he boards his jet. Shortly afterward, she confronts Lucky to taunt him, while insisting the whole time that Aiden was really a Cassadine and that Elizabeth's third DNA test was the tampered one. Lucky demands her to leave.
While searching from a recently missing-in-action Luke in Florida, Lulu and her boyfriend Dante learn from a pimp that Luke is somewhere doing business with Helena. The two arrive on Cassadine Island where they confront Helena about Luke's whereabouts. Helena later threatens to cause the Spencer family pain by making them lose Luke. Helena has a plan to get revenge on Spencers for the deaths of both her sons.
On September 28, 2011 Luke's son, Ethan, is wandering in Nik's home. While there, he find a photo of Laura and is smacked in the head with vase by Helena. Helena sees someone passing by while she and Ethan talk.
On January 11, 2012, Helena is seen lurking the tunnels of Wyndemere holding a dagger and listening in on Ethan and "Cassandra's" conversation. Helena reappears on February 24, 2012 when she shows her face to Ethan and "Cassandra". She insists it's time to end the charade and tell Ethan the truth. Ethan's shocked when he realizes that Helena and "Cassandra" know each other. It hits him even harder, when "Cassandra" announces under the pressure of Helena that she really is Irina Cassadine, Helena's daughter. Irina tells Ethan that she was forced to play the part and take a place in Helena's never ending vendetta against Laura and the Spencer family. Helena seeks her goal when she informs Ethan that she wanted him to fall for Irina in order to break his heart. Irina tries to convince Ethan that she's fallen in love with him and doesn't want to lose him. Helena claims that Irina is still playing him and then she lets two of her men bring in a beaten up Luke. Ethan is shocked to learn that Luke was captured by Helena all this time since he thought his father was on one of his adventurous trips. Helena then announces that one of them is going to die. She ends up shooting her daughter, killing her.
On November 30, 2012, Helena is seen once again as Robert Scorpio pays her a visit. After she is told of Robert's suspicion that Cesar Faison is still alive, Helena calls Faison once Robert leaves to warn him that Robert is on to him.
Read more about this topic: Helena Cassadine, Storylines