Notable Alumni
- Nobel Prize laureates: Daniel Kahneman (economics 2002), David Gross (physics 2004), Avram Hershko (chemistry 2004), Robert Aumann (economics 2005), and Ada Yonath (chemistry 2009).
- Educators: Brother Rafael S. Donato FSC, Ed.D., was a Filipino De La Salle Brother and was the past President of De La Salle University Manila, University of St. La Salle, De La Salle Lipa, La Salle Green Hills and De La Salle Araneta University.
- Fields Medal laureate: Elon Lindenstrauss (2010)
- Presidents of Israel: Ephraim Katzir, Yitzhak Navon, Moshe Katsav
- Prime Ministers of Israel: Ehud Barak, Ariel Sharon, Ehud Olmert
- Supreme Court Justices: Aharon Barak, Dorit Beinisch, Menachem Elon, Elyakim Rubinstein, Meir Shamgar, Jacob Turkel, Yitzhak Zamir, Salim Joubran
- Members of the Knesset: Colette Avital, Yael Dayan, Taleb el-Sana, Dalia Itzik, Roman Bronfman, David Rotem, Ahmed Tibi, Avigdor Lieberman, Dov Khenin, Danny Danon, Shulamit Aloni, Rachel Adato, Ze'ev Elkin, Roni Bar-On, Ze'ev Bielski, Yohanan Plesner, David Rotem, Reuven Rivlin, Yuval Steinitz, Dan Meridor, Yisrael Katz, Jamal Zahalka, Shai Hermesh, Zvulun Orlev, Taleb el-Sana, Menachem Ben-Sasson, Ya'akov Ne'eman, Geulah Cohen
- Foreign service: Naomi Ben-Ami, Gabriela Shalev
- Sports and culture: Yochanan Vollach, Itzik Kornfein, Adin Talbar
- Culture: Natalie Portman, Uri Zohar
- Archaeologists: Ruth Amiran, Trude Dothan, Aren Maeir, Benjamin Mazar, Amihai Mazar, Eilat Mazar, Yigael Yadin
- Activists: Elie Yossef
- Journalists: Khaled Abu Toameh, Ron Ben-Yishai, Nahum Barnea, Zvi Yehezkeli, Sayed Kashua, Amira Hass, Akiva Eldar, Yossi Melman, Meron Benvenisti, Tom Segev, Haviv Rettig, Dan Margalit, Ya'akov Ahimeir, Michael Bar-Zohar, David Witzthum, Haim Gouri, Ehud Yaari, Amos Kenan, Boaz Evron
- Writers: Yehuda Amichai, Galila Ron-Feder Amit, Aharon Appelfeld, Netiva Ben-Yehuda, Elias Chacour, Yael Dayan, David Grossman, Batya Gur, Shifra Horn, Amos Oz, A. B. Yehoshua, Amnon Jackont, Amalia Kahana-Carmon, Yehoshua Kenaz, Anton Shammas, Natan Yonatan, Helen Epstein.
- Academics: Ahron Bregman, Richard I. Cohen, Uri Davis, Gerson Goldhaber, Igal Talmi, Haim Harari, Joshua Jortner, Alexander Levitzki, Efraim Karsh, Asa Kasher, Walter Laqueur, Avishai Margalit, Dana Olmert, Miri Rubin, Ada Yonath, Amit Schejter, Benjamin Elazari Volcani
- Lawyers: Elias Khoury, Menachem Mazuz, Ya'akov Ne'eman, Malcolm Shaw
- Soldiers: Yonatan "Yoni" Netanyahu
- Theologians: Fr Malachi Martin, Yigal Arnon
- Physicists: David Gross, Igal Talmi, Haim Harari, Amikam Aharoni, Micha Tomkiewicz
- Chemists: Renata Reisfeld, Aaron Barkatt
- Business: Léo Apotheker (former CEO of Hewlett-Packard and SAP), Orit Gadiesh (Chairman of Bain & Company), Dina Dublon (Board member of Microsoft, Accenture and PepsiCo), Gil Shwed (CEO and chairman Check Point Software Technologies), Eli Hurvitz (CEO 1976–2002 Teva Pharmaceuticals), Kobi Alexander (former CEO of Comverse Technology)
- Mathematicians: Rami Grossberg (1986), Joram Lindenstrauss (1962), Moshe Machover (1962), Saharon Shelah (1969), Oded Schramm (1987)
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