Haemophilia A - Severity

Severity

There are numerous different mutations which cause haemophilia A. Due to differences in changes to the gene involved (and the subsequent resulting protein), patients with haemophilia often have some level of active clotting factor. Individuals with less than 1% active factor are classified as having severe haemophilia, those with 1–5% active factor have moderate haemophilia, and those with mild haemophilia have between 5–40% of normal levels of active clotting factor.

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