Guido Masetti (November 22, 1907 – November 26, 1993) was an Italian football goalkeeper. Born in Verona, he played for Hellas Verona and A.S. Roma (1929 to 1943) — with 339 matches and one Italian title in the 1941-42 season.
He was considered to be one of the strongest goalkeepers in 1930s and 1940s, but for the Italian national team he was merely used as a stand-in for Giampiero Combi and Aldo Olivieri. Masetti won two World Cups in 1934 and 1938 without playing in any of the matches.
In 1950s, he was manager of A.S. Roma for ten games (5 in season 1950-51, and another 5 in season 1956-57). He died at age 86 in Rome.