Health
Great Danes, like most giant dogs, have a fairly slow metabolism. This results in less energy and less food consumption per pound of dog than in small breeds. Great Danes have some health problems that are common to large breeds, including gastric dilatation-volvulus (GDV). The average life span of Great Danes is 6 to 8 years. Like many larger breeds, Great Danes are at particular risk for hip dysplasia.
Dilated cardiomyopathy (DCM) and many congenital heart diseases are also commonly found in the Great Dane, leading to its nickname: the Heartbreak breed, in conjunction with its shorter lifespan. Great Danes also may carry the merle gene, which is part of the genetic makeup that creates the harlequin coloring. The merle gene is an incomplete dominant, meaning only one copy of the gene is needed to show the merle coloring; two merle genes produce excessive white markings and many health issues such as deafness, blindness, or other debilitating ocular issues.
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—Henry David Thoreau (1817–1862)