Test Calibration
Because tests can be incorrect (yielding a false-negative or a false-positive), results should be interpreted in the context of the history, physical findings, and other test results in the individual being tested. It is within this context that the sensitivity and specificity of the "gold standard" test is determined.
When the gold standard is not a perfect one, its sensitivity and specificity must be calibrated against more accurate tests or against the definition of the condition. This calibration is especially important when a perfect test is available only by autopsy. It's important to emphasize that a test has to meet some interobservers agreement, to avoid some bias induced by the study itself.(Complications and Validity of Pulmonary Angiography in Acute Pulmonary Embolism Circulation 1992;85:462-468 )
Calibration errors can lead to misdiagnosis.
Read more about this topic: Gold Standard (test)
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“First follow Nature, and your judgment frame
By her just standard, which is still the same;
Unerring Nature, still divinely bright,
One clear, unchanged, and universal light,
Life, force, and beauty must to all impart,
At once the source, and end, and test of art.”
—Alexander Pope (1688–1744)