Species Distribution
Mice genetically engineered to lack glutathione peroxidase 1 (Gpx1 knockout mice) are grossly phenotypically normal and have normal lifespans, indicating this enzyme is not critical for life. However, Gpx1 -/- mice develop cataracts at an early age and exhibit defects in muscle satellite cell proliferation.
However, glutathione peroxidase 4 knockout mice die during early embryonic development.
Some evidence, though, indicates reduced levels of glutathione peroxidase 4 can increase life expectancy in mice.
No information is available on knockouts of the other isozymes.
The bovine erythrocyte enzyme has a molecular weight of 84 kDa.
Read more about this topic: Glutathione Peroxidase
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