George Weiss may refer to:
- George David Weiss (1921–2010), songwriter
- George Henry Weiss (1898–1946), writer
- George Weiss (baseball) (1895–1972), baseball executive
- George Weiss (producer) (born 1921), film producer
- George Michael Weiss (1697–1762), Dutch Reformed clergyman who worked in New York and Pennsylvania