George Mathews may refer to:
- George Mathews (Georgia) (1739–1812), Governor of Georgia
- George Mathews (judge) (1774–1836), his son, Chief Justice of the Louisiana Supreme Court
- George A. Mathews (1852–1941), Delegate from Dakota Territory to the United States House of Representatives
- George Mathews (actor) (1911–1984), American actor
- George Ballard Mathews (1861–1922), English mathematician
- Geevarghese Mor Coorilose (George Mathews Nalunnakkal, born 1965), Syriac Orthodox bishop
- George W. Mathews (1874–1906), Medal of Honor recipient
- George C. Mathews, American economist