George Jeffreys may refer to:
- George Jeffreys (composer) (c. 1610–1685), composer and organist to Charles I
- George Jeffreys, 1st Baron Jeffreys (1645–1689), British politician & jurist
- George Jeffreys, 1st Baron Jeffreys (second creation) (1878–1960), British soldier & politician
- George Jeffreys (pastor) (1889–1962), British religious leader
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