William Pitt
For George III, Pitt's appointment was a great victory. It proved that he was able to appoint Prime Ministers on the basis of his own interpretation of the public mood without having to follow the choice of the current majority in the House of Commons. Throughout Pitt's ministry, George supported many of Pitt's political aims and created new peers at an unprecedented rate to increase the number of Pitt's supporters in the House of Lords. During and after Pitt's ministry, George III was extremely popular in Britain. The British people admired him for his piety, and for remaining faithful to his wife. He was fond of his children, and was devastated at the death of two of his sons in infancy in 1782 and 1783 respectively. Nevertheless, he set his children a strict regimen. They were expected to attend rigorous lessons from seven in the morning, and to lead lives of religious observance and virtue. When his children strayed from George's own principles of righteousness, as his sons did as young adults, he was dismayed and disappointed.
By this time George's health was deteriorating. He suffered from a mental illness, which was possibly a symptom of the genetic disease porphyria, although this has been questioned. A study of samples of the King's hair published in 2005 revealed high levels of arsenic, a possible trigger for the disease. The source of the arsenic is not known, but it could have been a component of medicines or cosmetics. The King may have suffered a brief episode of disease in 1765, but a longer episode began in the summer of 1788. At the end of the parliamentary session, he went to Cheltenham Spa to recuperate. It was the furthest he had ever been from London—just short of 100 miles (150 km)—but his condition worsened. In November he became seriously deranged, sometimes speaking for many hours without pause, causing him to foam at the mouth and making his voice hoarse. With his doctors largely at a loss to explain his illness, spurious stories about his condition spread, such as the claim that he shook hands with a tree in the mistaken belief that it was the King of Prussia. Treatment for mental illness was primitive by modern standards, and the King's doctors, who included Francis Willis, treated the King by forcibly restraining him until he was calm, or applying caustic poultices to draw out "evil humours".
In the reconvened Parliament, Fox and Pitt wrangled over the terms of a regency during the King's incapacity. While both agreed that it would be most reasonable for George III's eldest son and heir apparent, the Prince of Wales, to act as Regent, to Pitt’s consternation Fox suggested that it was the Prince of Wales's absolute right to act on his ill father's behalf with full powers. Pitt, fearing he would be removed from office if the Prince of Wales were empowered, argued that it was for Parliament to nominate a Regent, and wanted to restrict the Regent's authority. In February 1789, the Regency Bill, authorising the Prince of Wales to act as Prince Regent, was introduced and passed in the House of Commons, but before the House of Lords could pass the bill, George III recovered.
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