George Gaines may refer to:
- George Strother Gaines (1784–1873), American leader in the Mississippi Territory
- George Gaines (set decorator), Academy Award winner for Best Art Direction - Set Decoration
- George Gaynes, Finnish-born American actor (Police Academy)
Famous quotes containing the word george:
“Either he’s dead or my watch has stopped!”
—Robert Pirosh, U.S. screenwriter, George Seaton, George Oppenheimer, and Sam Wood. Dr. Hugo Z. Hackenbush (Groucho Marx)