George Gaines may refer to:
- George Strother Gaines (1784–1873), American leader in the Mississippi Territory
- George Gaines (set decorator), Academy Award winner for Best Art Direction - Set Decoration
- George Gaynes, Finnish-born American actor (Police Academy)
Famous quotes containing the word george:
“Love your neighbour, yet pull not down your hedge.”
—British proverb, George Herbert, Jacula Prudentum (1651)