Gene Regulatory Network - Network Connectivity

Network Connectivity

Empirical data indicate that biological gene networks are sparsely connected, and that the average number of upstream-regulators per gene is less than two. Theoretical results show that selection for robust gene networks will favor minimally complex, more sparsely connected, networks. These results suggest that a sparse, minimally connected, genetic architecture may be a fundamental design constraint shaping the evolution of gene network complexity.

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Famous quotes containing the word network:

    How have I been able to live so long outside Nature without identifying myself with it? Everything lives, moves, everything corresponds; the magnetic rays, emanating either from myself or from others, cross the limitless chain of created things unimpeded; it is a transparent network that covers the world, and its slender threads communicate themselves by degrees to the planets and stars. Captive now upon earth, I commune with the chorus of the stars who share in my joys and sorrows.
    Gérard De Nerval (1808–1855)