Combined Approaches
Programs such as Maker combine extrinsic and ab initio approaches by mapping protein and EST data to the genome to validate ab initio predictions. Augustus, which may be used as part of the Maker pipeline, can also incorporate hints in the form of EST alignments or protein profiles to increase the accuracy of the gene prediction.
Read more about this topic: Gene Prediction
Famous quotes containing the words combined and/or approaches:
“... overconfidence in one’s own ability is the root of much evil. Vanity, egoism, is the deadliest of all characteristics. This vanity, combined with extreme ignorance of conditions the knowledge of which is the very A B C of business and of life, produces more shipwrecks and heartaches than any other part of our mental make-up.”
—Alice Foote MacDougall (1867–1945)
“As the truest society approaches always nearer to solitude, so the most excellent speech finally falls into Silence. Silence is audible to all men, at all times, and in all places. She is when we hear inwardly, sound when we hear outwardly. Creation has not displaced her, but is her visible framework and foil. All sounds are her servants, and purveyors, proclaiming not only that their mistress is, but is a rare mistress, and earnestly to be sought after.”
—Henry David Thoreau (1817–1862)