gamma-Aminobutyric Acid - GABA As A Supplement

GABA As A Supplement

A number of commercial sources sell formulations of GABA for use as a dietary supplement, sometimes for sublingual administration. These sources typically claim that the supplement has a calming effect. There is some disagreement as to whether or not these claims can be backed up scientifically. For example, there is evidence stating that the calming effects of GABA can be seen observably in the human brain after administration of GABA as an oral supplement. There is also evidence that GABA does not cross the blood–brain barrier at significant levels.

There are some over-the-counter supplements such as Picamilon that cross the blood–brain barrier as a prodrug that later hydrolyzes into GABA and niacin.