Unwritten Sequel
Foundation and Earth takes place only some 500 years into the 1,000-year Seldon Plan. As detailed by his wife in It's Been a Good Life, Asimov intended to write a sequel, but his attempts were fruitless. He did not know what to do next. This is why he wrote the prequels (Prelude to Foundation and Forward the Foundation) instead.
Trevize mentions that no human ship has ever penetrated the Magellanic Clouds, nor the Andromeda Galaxy or galaxies beyond that. Intelligent aliens have been mentioned in the short story Blind Alley (who end up fleeing to the Magellanic Clouds). No reason is given why humans have not visited other galaxies, which would seem to be within range of the hyperspace drive.
Read more about this topic: Foundation And Earth
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