Follicle-stimulating Hormone - Potential Role in Vascularization of Solid Tumors

Potential Role in Vascularization of Solid Tumors

Elevated FSH receptor levels have been detected in the endothelia of tumor vasculature in a very wide range of solid tumors. FSH binding is thought to upregulate neovascularization via at least two mechanisms - one in the VEGF pathway, and the other VEGF independent - related to the development of umbilical vasculature when physiological. This presents possible use of FSH and FSH-receptor antagonists as an anti tumor angiogenesis therapy (cf. avastin for current anti-VEGF approaches).

Read more about this topic:  Follicle-stimulating Hormone

Famous quotes containing the words potential, role and/or solid:

    Most days I feel like an acrobat high above a crowd out of which my own parents, my in-laws, potential employers, phantoms of “other women who do it” and a thousand faceless eyes stare up.
    —Anonymous Mother. Ourselves and Our Children, by Boston Women’s Health Book Collective, ch. 2 (1978)

    Man, truly the animal that talks, is the only one that needs conversations to propagate its species.... In love conversations play an almost greater role than anything else. Love is the most talkative of all feelings and consists to a great extent completely of talkativeness.
    Robert Musil (1880–1942)

    An idea ran back and forward in his head like a blind man, knocking over the solid furniture.
    F. Scott Fitzgerald (1896–1940)