Potential Role in Vascularization of Solid Tumors
Elevated FSH receptor levels have been detected in the endothelia of tumor vasculature in a very wide range of solid tumors. FSH binding is thought to upregulate neovascularization via at least two mechanisms - one in the VEGF pathway, and the other VEGF independent - related to the development of umbilical vasculature when physiological. This presents possible use of FSH and FSH-receptor antagonists as an anti tumor angiogenesis therapy (cf. avastin for current anti-VEGF approaches).
Read more about this topic: Follicle-stimulating Hormone
Famous quotes containing the words potential, role and/or solid:
“And what is the potential man, after all? Is he not the sum of all that is human? Divine, in other words?”
—Henry Miller (1891–1980)
“The addition of a helpless, needy infant to a couple’s life limits freedom of movement, changes role expectancies, places physical demands on parents, and restricts spontaneity.”
—Jerrold Lee Shapiro (20th century)
“We have the pleasures suitable to our lot; let us not usurp those of greatness. Ours are more natural and all the more solid and sure for being humbler. Since we will not do so out of conscience, at least out of ambition let us reject ambition.”
—Michel de Montaigne (1533–1592)