Literature, Films, and TV
- Star Trek V: The Final Frontier, the fifth feature film based on Star Trek
- Final Frontier, a Star Trek novel by Diane Carey
- Final Frontier, a scenario on the expansion pack Civilization IV: Beyond the Sword for the video game Civilization IV
- "The Final Frontier" (Mad About You), the final episode (later split into two parts) of the 1990s American sitcom Mad About You
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