Fibrinogen

Fibrinogen (factor I) is a soluble, 340 kDa plasma glycoprotein, that is converted by thrombin into fibrin during blood clot formation. Fibrinogen is synthesized in the liver by the hepatocytes. The concentration of fibrin in the blood plasma is 1.5-4.0 g/L (normally measured using the Clauss method), or about 7 µM.