Mechanism of Action
Fexofenadine is a second-generation selectively peripheral H1-blocker of the GI tract, large blood vessels, and bronchial smooth muscle. Blockage prevents the activation of the H1 receptors by histamine, preventing the symptoms associated with allergies from occurring. Fexofenadine cannot cross the blood–brain barrier and therefore does not cause drowsiness. It also exhibits no anticholinergic, antidopaminergic, alpha1-adrenergic, or beta-adrenergic-receptor-blocking effects.
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“A mechanism of some kind stands between us and almost every act of our lives.”
—Sarah Patton Boyle, U.S. civil rights activist and author. The Desegregated Heart, part 3, ch. 2 (1962)
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—Ralph Waldo Emerson (1803–1882)