Physiology
Factor IX is produced as a zymogen, an inactive precursor. It is processed to remove the signal peptide, glycosylated and then cleaved by factor XIa (of the contact pathway) or factor VIIa (of the tissue factor pathway) to produce a two-chain form where the chains are linked by a disulfide bridge. When activated into factor IXa, in the presence of Ca2+, membrane phospholipids, and a Factor VIII cofactor, it hydrolyses one arginine-isoleucine bond in factor X to form factor Xa.
Factor IX is inhibited by antithrombin.
Factor IX expression increases with age in humans and mice. In mouse models mutations within the promoter region of factor IX have an age-dependent phenotype.
Read more about this topic: Factor IX
Famous quotes containing the word physiology:
“If church prelates, past or present, had even an inkling of physiology they’d realise that what they term this inner ugliness creates and nourishes the hearing ear, the seeing eye, the active mind, and energetic body of man and woman, in the same way that dirt and dung at the roots give the plant its delicate leaves and the full-blown rose.”
—Sean O’Casey (1884–1964)
“A physician’s physiology has much the same relation to his power of healing as a cleric’s divinity has to his power of influencing conduct.”
—Samuel Butler (1835–1902)
“I have more in common with a Mexican man than with a white woman.... This opinion ... chagrins women who sincerely believe our female physiology unequivocally binds all women throughout the world, despite the compounded social prejudices that daily affect us all in different ways. Although women everywhere experience life differently from men everywhere, white women are members of a race that has proclaimed itself globally superior for hundreds of years.”
—Ana Castillo (b. 1953)