Fab Five may refer to:
- Fab Five (University of Michigan), the 1991 University of Michigan men's basketball freshman recruiting class
- Fab Five, the United States women's gymnastics team at the 2012 Summer Olympics (also known as the Fierce Five)
- Fab Five, the English rock band Duran Duran compared to the Fab Four of The Beatles
- Fab Five, the five stars of television show Queer Eye for the Straight Guy
- FAB 5, a Greek reality TV show
- Fab Five: The Texas Cheerleader Scandal, a 2008 movie
- The Fab Five (film), a 2011 documentary on the above group
- Fab Five Freddy (born 1959), an American hip hop historian, hip hop pioneer and former graffiti artist