Disease
- Excitatory synapses have a fundamental role in information processing within the brain and throughout the peripheral nervous system. Usually situated on dendritic spines, or neuronal membrane protrusions on which glutamate receptors and postsynaptic density components are concentrated, excitatory synapses aid in the electrical transmission of neuronal signals. The physical morphology of synapses is crucial in understanding their function, and it is well documented that the inappropriate loss of synaptic stability leads to the disruption of neuronal circuits and the resulting neurological diseases. Although there are innumerable different causes for different neurodegenerative illnesses, such as genetic dispositions or mutations, the normal aging process, parasitic and viral causes, or drug use, many can be traced back to dysfunctional signaling between the neurons themselves, often at the synapse.
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Famous quotes containing the word disease:
“Man is an exception, whatever else he is. If he is not the image of God, then he is a disease of the dust. If it is not true that a divine being fell, then we can only say that one of the animals went entirely off its head.”
—Gilbert Keith Chesterton (1874–1936)
“The artistic temperament is a disease that affects amateurs.... Artists of a large and wholesome vitality get rid of their art easily, as they breathe easily or perspire easily. But in artists of less force, the thing becomes a pressure, and produces a definite pain, which is called the artistic temperament.”
—Gilbert Keith Chesterton (1874–1936)
“It is useless to check the vain dunce who has caught the mania of scribbling, whether prose or poetry, canzonets or criticisms,—let such a one go on till the disease exhausts itself. Opposition like water, thrown on burning oil, but increases the evil, because a person of weak judgment will seldom listen to reason, but become obstinate under reproof.”
—Sarah Josepha Buell Hale 1788–1879, U.S. novelist, poet and women’s magazine editor. American Ladies Magazine, pp. 36-40 (December 1828)